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· What is Myasthenia Gravis?

Myasthenia gravis is a chronic autoimmune, neuromuscular disease that causes weakness in the skeletal muscles that worsens after periods of activity and improves after periods of rest. These muscles are in charge of functions involving breathing and moving parts of the body, including the arms and legs.

· What happens in myasthenia gravis?

In myasthenia gravis, your immune system produces antibodies that block or destroy many of your muscles' receptor sites for a neurotransmitter called acetylcholine. With fewer receptor sites available, your muscles receive fewer nerve signals, resulting in weakness.

· How does myasthenia gravis affect the body?

Myasthenia gravis is a chronic autoimmune disorder in which antibodies destroy neuromuscular connections. This causes problems with communication between nerves and muscle, resulting in weakness of the skeletal muscles. It affects the voluntary muscles of the body, especially the eyes, mouth, throat, and limbs.

· What happens if myasthenia gravis is left untreated?

Serious complications like these can result in injury or even death if left untreated. Myasthenia gravis happens more often in young women (under 40) and older men (over 60), but can impact anyone at any age.

· Is there any cure for myasthenia gravis?

There is no cure for myasthenia gravis, but it is treated with medications and sometimes surgery. You may be put on a drug called pyridostigmine (Mestinon), which increases the amount of acetylcholine available to stimulate the receptors.

· What is a lambert-Eaton syndrome?

Lambert-Eaton syndrome is a condition in which the body's immune system attacks the connections between nerves and muscles (the voltage-gated calcium channels). It is most often seen in people with small cell lung cancer or other cancers, but it can also occur in people without cancer.

· Is Lambert Eaton syndrome fatal?

In LEMS, eye muscle weakness, when present, tends to be mild and, unlike with MG, is rarely the only symptom of the disease. Severe respiratory muscle weakness, which can be fatal in MG, is rare in LEMS. The autonomic symptoms which affect most LEMS patients are not present in MG.

· Is Lambert-Eaton syndrome hereditary?

LEMS is not a hereditary disease, but people who have some variants of immune-related HLA genes are more susceptible to LEMS.

· Can myasthenia gravis run in families?

In most cases, myasthenia gravis is not inherited and occurs in people with no history of the disorder in their family. About 3 to 5 percent of affected individuals have other family members with myasthenia gravis or other autoimmune disorders, but the inheritance pattern is unknown.

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