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The spermatozoa chromatin is a tightly packed structure because of disulfide cross linkages between protamines that allow compaction of nuclear head and protect the DNA from stress and breakage.
The origin of Sperm DNA Fragmentation is multifactorial. Some of the factors associated with increased sperm DNA damage are tobacco use,chemo therapy, testicular carcinoma.
Human fertilization involves the direct interaction of the sperm and the oocyte, fusion of the cell membranes, and union of male and female gamete genomes. Although a small percentage of spermatozoa from fertile men also possess detectable levels of DNA damage, which is repaired by oocyte cytoplasm, there is evidence to show that the spermatozoa of infertile men possess substantially more DNA damage and that this damage may adversely affect reproductive outcomes.
Sperm DNA fragmentation defects can help couples decide on what fertility modality and possible lifestyle modifications they can employ that may increase their chances of conception. ICSI is advised when DFI is above cut off levels. There is higher rate of DNA damage in ejaculated or epididymal sperm than intratesticular spermatozoa, hence use of intratesticular from high DFI men is recommended for ICSI.There is evidence to suggest that sperm DNA damage is associated with poor pregnancy outcome after standard IVF
The cost of the Sperm DNA Fragmentation test is given above. The cost of Sperm DNA Fragmentation in India is lower than that in other countries. The treatment for Sperm DNA Fragmentation being high is a combination of weight loss, Stopping smoking and alcohol, Zinc along with other treatments. Sperm preparation by Double density centrifugation or MACS sorting can also help in the treatment. To know more Please call us on 9819938916 or mail us on email@example.com. To read more about male infertility testing please click here To read the wikipedia article on DNA fragmentation, click here