Mother can pass certain infections to the foetus in-utero or during delivery which can cause birth defects in the baby. Early detection of these infections is crucial to prevent congenital anomalies and complication. TORCH panel is a group of tests used to screen newborn (with signs/symptoms or maternal history) and pregnant women (with past bad obstetric history or first trimester infection) to detect IgM + IgG antibodies in serum against 4 infections viz. toxoplasma, rubella, cytomegalovirus and herpes. These antibodies are produced by immune system when exposed to the infectious agents. Testing is done by ELISA/CLIA methods. A normal test result means undetectable antibodies in the blood and indicates no exposure to infection. Positive test means patient has considerable antibody levels against that particular infection. Presence of IgM and absence of IgG or presence of both IgG + IgM indicates recent infection. Presence of IgG without IgM favours past infection. Depending upon which infection is tested positive, further testing with additional specific tests should be done to confirm these results.This profile consists of following tests -rubella toxoplasma,cytomegalo virus and herpes.